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Acute toxicity |
LD50 Oral - Rat - male - 770 mg/kg (OECD Test Guideline 401) LC50 Inhalation - Rat - male and female - 4 h - 7,8 mg/l - vapor (OECD Test Guideline 403) LD50 Dermal - Rabbit - male - 4.890 mg/kg (OECD Test Guideline 402) |
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Skin corrosion/irritation |
Skin - Rabbit Result: irritating (OECD Test Guideline 404) |
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Serious eye damage/eye irritation |
Eyes - Rabbit Result: Eye irritation (OECD Test Guideline 405) |
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Respiratory or skin sensitization |
Local lymph node assay (LLNA) - Mouse Result: negative (OECD Test Guideline 429) |
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Toxicity to Animal |
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE Acute oral toxicity (LD50): 689 mg/kg [Rat]. |
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Toxic Effects on Human |
May cause damage to the following organs: upper respiratory tract. Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation (lung irritant, lung sensitizer). |
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Carcinogenicity |
Presumed to have carcinogenic potential for humans |
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Germ cell mutagenicity |
Test Type: Ames test Test system: S. typhimurium Metabolic activation: with and without metabolic activation Result: positive Remarks: (ECHA) Test Type: Ames test Test system: Escherichia coli Metabolic activation: without metabolic activation Method: OECD Test Guideline 471 Result: positive Test Type: In vitro mammalian cell gene mutation test Test system: human lymphoblastoid cells Metabolic activation: without metabolic activation Method: OECD Test Guideline 476 Result: positive Test Type: In vitro mammalian cell gene mutation test Test system: human lymphoblastoid cells Metabolic activation: without metabolic activation Result: positive Remarks: (ECHA) Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster lung cells Metabolic activation: with and without metabolic activation Result: positive Remarks: (ECHA) Test Type: unscheduled DNA synthesis assay Test system: rat hepatocytes Metabolic activation: without metabolic activation Method: OECD Test Guideline 482 Result: positive Test Type: Micronucleus test Species: Mouse Application Route: Intraperitoneal Method: OECD Test Guideline 474 Result: negative Test Type: Mutagenicity (mammal cell test): micronucleus. Species: Mouse Cell type: Red blood cells (erythrocytes) Application Route: Oral Method: OECD Test Guideline 474 Result: negative Test Type: sister chromatid exchange assay Species: Rat Cell type: mammary gland Application Route: inhalation (vapor) Result: negative Remarks: (ECHA) Species: Drosophila melanogaster Cell type: sperm Application Route: Inhalation Method: OECD Test Guideline 477 Result: positive Test Type: Transgenic rodent somatic cell gene mutation assay Species: Mouse Application Route: Intraperitoneal Result: negative Remarks: (ECHA) |
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Reproductive toxicity |
No data available |
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Specific target organ toxicity - single exposure |
May cause respiratory irritation. |
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Special Remarks on other Toxi Effects on Humans |
Acute Potential Health Effects: Skin: Causes skin irritation. May cause skin sensitization, an allergic reation, which becomes evident upon re-exposure to this material. Eyes: Causes eye irritation. Ingestion: Causes gastrointestinal (digestive) tract irritation with nausea, vomiting, and diarrhea. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May cause chemical pneumonitis and pulmonary edema, inflammation, edema of bronchi and larynx. Chronic Potential Health Effects: Repeated or prolonged skin exposure may cause allergic reactions in sensitive individuals. Repeated or prolonged exposure by inhalation may affect respiration and metabolism. |
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Endocrine disrupting properties |
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher Repeated dose toxicity - Rat - male and female - Oral - 90 d - NOAEL (No observed adverse effect level) - 37,5 mg/kg Remarks: Subchronic toxicity Repeated dose toxicity - Mouse - male and female - Inhalation - 104 Weeks RTECS: KI0525000 Acts as a simple asphyxiant by displacing air., anesthetic effects, Difficulty in breathing, Headache, Dizziness, Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Provokes tears., Effects due to ingestion may include:, Gastrointestinal discomfort, Central nervous system depression, Paresthesia., Drowsiness, Convulsions, Conjunctivitis., Pulmonary edema. Effects may be delayed., Irregular breathing., Stomach/intestinal disorders, Nausea, Vomiting, Increased liver enzymes., Weakness, Heavy or prolonged skin exposure may result in the absorption of harmful amounts of material. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Pancreas . |